AG 490
- Product Name
- AG 490
- CAS No.
- 134036-52-5
- Chemical Name
- AG 490
- Synonyms
- AG 490;(E/Z)-AG490;TYRPHOSTIN B42;AG 490 USP/EP/BP;TYROPHOSTIN AG490;TYRPHOSTIN AG 490;(E/Z)-Tyrphostin B42;AG 490, Tryphostin B42;(E/Z)-Tyrphostin AG490;TYRPHOSTIN AG 490, 99+%
- CBNumber
- CB7779213
- Molecular Formula
- C17H14N2O3
- Formula Weight
- 294.3
- MOL File
- 134036-52-5.mol
AG 490 Property
- Melting point:
- 215
- Boiling point:
- 615.2±55.0 °C(Predicted)
- Density
- 1.337±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- ethanol: 5 mg/mL
- form
- solid
- pka
- 8.82±0.35(Predicted)
- color
- yellow
- CAS DataBase Reference
- 134036-52-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-50-25
- Safety Statements
- 26-36-61-45
- WGK Germany
- 1
- Hazard Note
- Irritant/Keep Cold under -20C
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- J61715
- Product name
- Tyrphostin B42, 99+%
- Packaging
- 25mg
- Price
- $178
- Updated
- 2021/12/16
- Product number
- J61715
- Product name
- Tyrphostin B42, 99+%
- Packaging
- 100mg
- Price
- $329
- Updated
- 2021/12/16
- Product number
- 0414
- Product name
- AG 490
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $520
- Updated
- 2021/12/16
- Product number
- 0414
- Product name
- AG 490
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $124
- Updated
- 2021/12/16
- Product number
- T9250-15
- Product name
- Tyrphostin AG 490
- Packaging
- 25mg
- Price
- $239
- Updated
- 2021/12/16
AG 490 Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow-Green Crystal
Uses
A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
Uses
Tyrphostin B42 is used in acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors.
Definition
ChEBI: Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide.